Expression Enhancement of Trastuzumab in CHO Cells Using Codon Optimization and Promoter Selection for Mammalian Expression Vector
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چکیده
منابع مشابه
P-128: Optimization of Human LH Gene Expression by Codon Usage Adaptation in CHO Cell Line
a:4:{s:10:"Background";s:897:"Human luteinizing hormone (hLH) belongs to glycoprotein hormones which is composed of two non-covalently linked subunit, α and β. The α-subunit is similar in all glycoprotein hormones, whereas the β-subunit is conferring the hormonal specificity. This hormone has important roles in the growth and maturity of sexual organs and secondary sexual characteristics and st...
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Background Human coagulation factor IX is a 57kDa plasma serine protease made in Liver which plays a vital role in the blood coagulation cascade. FIX deficiency causes severe disorder Hemophilia B or Christmas disease. Nowadays, recombinant proteins have important roles in treatment of diseases. Although, cultivated mammalian cells because of their ability for producing properly folded protein ...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Sciences and Drug Research
سال: 2019
ISSN: 0975-248X
DOI: 10.25004/ijpsdr.2019.110618